Effects of infusion of dopamine and nitroprusside on size of experimental myocardial infarct.

نویسندگان

  • C H Shatney
  • D J MacCarter
  • R C Lillehei
چکیده

Using a canine model for experimentally induced myocardial infarction via ligation of the left anterior descending coronary artery and using a stain for intracellular lactic dehydrogenase to directly measure the size of the infarct, we evaluated the influence of infusion of dopamine and sodium nifroprusside. Infusion of sodium nitroprusside (222 g/min) produced significant decreases in the mean blood pressure, total peripheral resistance, and left atrial pressure and reduced the volume of the infarct by 58 percent (P < 0.0025). The administration of dopamine (6 g/kgImiu) significantly improved the cardiac index and lowered the systemic

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عنوان ژورنال:
  • Chest

دوره 73 6  شماره 

صفحات  -

تاریخ انتشار 1978